Recent years have witnessed tremendous growth in the epidermal growth factor (EGF) family of peptide growth factors and the ErbB family of tyrosine kinases, the receptors for these factors. Accompanying this growth has been an increased appreciation for the roles these molecules play in tumorigenesis and in regulating cell proliferation and differentiation during development. Consequently, a significant question has been how diverse biological responses are specified by these hormones and receptors. Here we discuss several characteristics of hormone-receptor interactions and receptor (...) coupling that contribute to specificity: 1) a single EGF family hormone can bind multiple receptors; 2) a single ErbB family receptor can bind multiple hormones; 3) there are three distinct functional groups of EGF family hormones; 4) EGF family hormones can activate receptors in trans, and this heterodimerization diversifies biological responses; 5) ErbB3 requires a receptor partner for signaling; and 6) ErbB family receptors differentially couple to signaling pathways and biological responses. BioEssays 20:41–48, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

How are children raised in different cultures? What is the role of children in society? How are families and communities structured around them? Now in its third edition, this deeply engaging book delves into these questions by reviewing and cataloging the findings of over 100 years of anthropological scholarship dealing with childhood and adolescence. It is organized developmentally, moving from infancy through to adolescence and early adulthood, and enriched with anecdotes from ethnography and the daily media, to paint a nuanced (...) and credible picture of childhood in different cultures, past and present. This new edition has been expanded and updated with over 350 new sources, and introduces a number of new topics, including how children learn from the environment, middle childhood, and how culture is 'transmitted' between generations. It remains the essential book to read to understand what it means to be a child in our complex, ever-changing world. (shrink)

Theological basis -- Religion and health care -- The dignity of human life -- The integrity of the human person -- Implications for health care -- Theological principles in health care ethics -- Method -- The levels and questions of ethics -- Freedom and the moral agent -- Right and wrong -- Metaethics -- Method in Catholic bioethics -- Catholic method and birth control -- The principle of double effect -- Application -- Forgoing treatment, pillar one: ordinary and extraordinary means (...) -- Forgoing treatment, pillar two: killing and allowing to die -- Forgoing treatment, pillar three: decisions by competent patients -- Forgoing treatment, pillar three: decisions for incompetent patients -- Forgoing treatment, pillar three: advance directives -- Hydration and nutrition -- Physician-assisted suicide and euthanasia -- Medical futility -- Pain and pain management -- Ethics committees -- Embryonic stem cells and the beginning of human personhood -- Genetic engineering -- Allocating health care resources -- The use and misuse of the allocation argument. (shrink)

Introduction / David F. Wright -- The natural ethic / Oliver O'Donovan -- Using the Bible in ethics / Howard Marshall -- From Christendom to pluralism / John Briggs -- Towards a theology of the state / Haddon Wilmer -- The challenge of Marxism / David Lyon -- Man in society / E. David Cook -- Human rights / John Gladwin -- Epilogue : tasks which await us / John Stott.

This study aimed to explore the role of two models of well-being in the prediction of psychological distress during the COVID-19 pandemic, namely PERMA and mature happiness. According to PERMA, well-being is mainly composed of five elements: positive emotions, engagement, relationships, meaning in life, and achievement. Instead, mature happiness is understood as a positive mental state characterized by inner harmony, calmness, acceptance, contentment, and satisfaction with life. Rooted in existential positive psychology, this harmony-based happiness represents the result of living in (...) balance between positive and negative aspects of one's life. We hypothesized that mature happiness would be a more prominent protective factor during the present pandemic than the PERMA composite. A total of 12,203 participants from 30 countries responded to an online survey including the Depression Anxiety Stress Scale (DASS-21), the PERMA-Profiler, and the Mature Happiness Scale-Revised (MHS-R). Confirmatory factor analyses indicated that PERMA and mature happiness were highly correlated, but nonetheless, they represented two separate factors. After controlling for demographic factors and country-level variables, both PERMA Well-being and MHS-R were negative predictors of psychological distress. Mature happiness was a better predictor of stress, anxiety, and general distress, while PERMA showed a higher prediction of depression. Mature happiness moderated the relation between the perceived noxious effects of the pandemic and all markers of distress (depression, anxiety, stress, and total DASS-21). Instead, PERMA acted as a moderator in the case of depression and stress. These findings indicate that inner harmony, according to the mature happiness theory, is an essential facet of well-being to be taken into consideration. The results of this study can also orient policies aimed to alleviate the negative effects of the pandemic on mental health through the promotion of well-being. (shrink)

Although it is rarely named, the majority of societies in the ethnographic record demarcate a period between early childhood and adolescence. Prominent signs of demarcation are, for the first time, pronounced gender separation in fact and in role definition; increased freedom of movement for boys, while girls may be bound more tightly to their mothers; and heightened expectations for socially responsible behavior. But above all, middle childhood is about coming out of the shadows of community life and assuming a distinct, (...) lifetime character. Naming and other rites of passage sometimes acknowledge this transition, but it is, reliably, marked by the assumption or assignment of specific chores or duties. Because the physiological changes at puberty are so much more dramatic, the transition from middle childhood is more often marked by a rite of passage than the entrance into this period. There is also an acknowledgment at the exit from middle childhood of near-adult levels of competence—as a herdsman or hunter or as gardener or infant-caretaker. (shrink)

Swenson's discovery of Kierkegaard for himself led him to resolve to devote his career to the task of making Kierkegaard available in translation to the ...

In lieu of an abstract, here is a brief excerpt of the content:On the NoseDavid F. Bell (bio)I recently underwent a COVID test. As the technician inserted the rather ominous cotton-tipped probe into my nostril, she told me that it was going to feel as if she were tickling my brain. Indeed… This experience, shared by many during the past three years, and likely multiple times, prompted me to think about my nose. Not since cocaine reentered American mainstream culture in (...) the 1970s and '80s—and found its way into countless movies that reflect the trend—has the nose been so central to a certain state of public life. It's difficult to find a film dealing with American culture from that period and beyond, from Scarface to The Wolf of Wall Street, in which there is not a scene depicting characters snorting the obligatory line or spoon of cocaine. Yes, snorting, sniffing, sneezing, ingesting the line through the nose and finishing leftover dust by collecting it with a moist finger, rubbing it lovingly against the front gum of the mouth. Freud's "Über Coca" looms ominously in the background, the work of a phase in Freud's professional career complicated by his obscure relationships with Parke-Davis (now a subsidiary of Pfizer) and Merck, pharmaceutical companies that supplied him with early samples to tickle his nose (Freud; Merkel). The Sacklers of the moment. In our day, Pfizer wants to transform our noses into defenses against the virus rather than conduits toward mind-altering dreams. In the wake of the Freud and William Halsted cocaine addictions chronicled by Howard Merkel, the irony of the contemporary link between Pfizer and the nose is patent.The nose: that orifice through which the virus creeps, the first stage in breathing, the first filter for air-borne pollutants. Recently, important immunological analyses of COVID have focused on the question of viral load, how much virus is necessary to overcome the nose's filtering function and reach the deeper airways leading to the lungs. The processes triggered by any of the major vaccines prepare antibody blueprints and actual antibodies that can be dispatched to the linings of the nose to counter the virus as soon as the body detects its presence. The Delta, Omicron, and subsequent variants remind us that the virus has mechanisms to challenge this response, namely, increased viral load that intensifies transmissibility and the potential to overwhelm antibodies. It seems, however, that [End Page 231] so-called breakthrough infections are still well controlled by the body's vaccinated immune system. Hysteria about the dangers of such incursions is partially a product of biased and often incorrect or incomplete media coverage of the COVID vaccine, which has terrified the vaccinated and fueled the skepticism of the unvaccinated.The virus tries to overpower and confuse the filtering nose in another way, more immediately apparent to our conscious selves. As many as eighty-five percent of COVID infections result in the loss of smell, generally recovered in about two to three weeks in sickened people who overcome the infection. About five percent of COVID victims, however, have not recovered their sense of smell six months or more after they have shed the virus.1 What might it mean to lose one's sense of smell? In our vision-oriented culture, both sound (the ear) and smell (the nose) have been less recognized as primary defense mechanisms than in other cultures. When one hears a sound, the first reaction is to prepare for a threat, before the sonic source is seen or understood. Orientation in the world, knowing from which direction the sound emanates, is key to preparing the body for an encounter with an unknown phenomenon: "To sound (an alarm) means to warn. Isn't any emerging sound understood as a warning? Any unexpected sonic occurrence is seen as an indication of something that is to come and that must be clarified rapidly" (Deshays 34). By the same token, to sample surroundings by sniffing what is in the air signals whether one should inhale or somehow try to hold one's breath in search of cleaner, more palatable air. Without olfaction, we are at potentially heightened risk of asphyxiation. We are more likely to... (shrink)

This article seeks to integrate the roles of structure and human agency in a theory of historical causation, using the fall of the Weimar Republic and in particular Henry Turner's book Hitler's Thirty Days to Power as a case study. Drawing on analogies from chaos theory, it argues that crisis situations in history exhibit sensitive dependence on local conditions, which are always changing. This undermines the distinction between causes and conditions . It urges instead a distinction between empowering and constraining (...) causes of specific human actions as a more fruitful model. The paper also discusses more briefly two other analogies to chaos theory: 1) similarity across differences in scale as applicable to different levels of individual and collective events, which are seen as homologous; 2) a model of branching as applicable to the totality of causes of a given event. (shrink)

Journal of Philosophy of Education, EarlyView.

I am becoming increasingly disturbed by the lack of under standing of science revealed by politicians, industrialists and the general public. I am also concerned about the widespread mis use of the word "scientific" which is more and more being used in situations where it is quite inappropriate. As a result, in some circumstances gross overestimates are made as to what science can do. In other circumstances the real power of science is foolishly underestimated and the contributions which it can (...) make are squandered. Science is God is an attempt to explain just what is meant by the scientific approach and to define more closoJ. y what the word "scientific" indicates. It is deliberately brief and controversial because I want it to be read. In fact, the material dealt with in each single chapter really deserves a whole book to itself. In the future I hope that I may be able to give to each subject such full treatment. Meanwhile I hope that this book will stimulate discussion about science and will increase understanding of it. DAVID F. (shrink)

If we do not, at some point in our life, face death—thinking hard and straight about it—we turn away from our authenticity. If that facing rejects irrational faith, dogmas, mystification, and personal immortality, is there yet a path free of despair? David Martin argues that participatory pantheism—the experience of the secular and the sacred both as a unity and as a mystery—provides such a path.

Focusing on general texts of moral theology, this study investigates how Roman Catholic medical ethics emerged in North America as a developed and self-conscious discipline. It applies questions that Roman Catholic moralists have been pondering for centuries to the relatively new field of medical ethics.

In March 2012, Joshua Foer presented a TED Talk to a mesmerized audience. As he began, Foer asked the audience members to close their eyes, and he proceeded to describe a scenario in which a series of striking images appeared as he talked his spectators through various architectural spaces in a house they were to imagine as their own. First, a group of nude bicyclists materialized at the front door, crashing before the very eyes of the bemused beholders, sending bicycle (...) pieces flying in all directions. An encounter with Sesame Street’s Cookie Monster in the entrance foyer ensued, during which salient details of the Muppet’s appearance were described down to the smell of his... (shrink)

In Losing Our Virtue: Why the Church Must Recover Its Moral Vision, theologian David Wells argues that the Church is in danger of losing its moral authority to speak to a culture whose moral fabric is torn. Although much of the Church has enjoyed success and growth over the past years, Wells laments a "hollowing out of evangelical conviction, a loss of the biblical word in its authoritative function, and an erosion of character to the point that today, no (...) discernible ethical differences are evident in behavior when those claiming to have been reborn and secularists are compared." The assurance of the Good News of the gospel has been traded for mere good feelings, truth has given way to perception, and morality has slid into personal preference. Losing Our Virtue is about the disintegrating moral culture that is contemporary society and what this disturbing loss means for the church. Wells covers the following in this bold critique: how the theologically emptied spirituality of the church is causing it to lose its moral bearings; an exploration of the wider dynamic at work in contemporary society between license and law; an exposition of the secular notion of salvation as heralded by our most trusted gurus -- advertisers and psychotherapists; a discussion of the contemporary view of the self; how guilt and sin have been replaced by empty psychological shame; an examination of the contradiction between the way we view ourselves in the midst of our own culture and the biblical view of persons as created, moral beings. Can the church still speak effectively to a culture that has become morally unraveled? Wells believes it can. In fact, says Wells, no time in this century has been more opportune for the Christian faith -- if the church can muster the courage to regain its moral weight and become a missionary of truth once more to a foundering world. - Publisher. (shrink)